Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.51 |
| ▸ | AKT1 | P31749 | 8/20 | 0.44 |
| ▸ | MTOR | P42345 | 5/20 | 0.44 |
| ▸ | DHFR | P00374 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437223 | 0.75 | FGFR1 (0.56) | DHFR | |
| SCHEMBL27953454 | 0.74 | DHFR (0.63) | DHFR | |
| SCHEMBL28809367 | 0.73 | DHFR (0.58) | DHFR | |
| SCHEMBL14694265 | 0.72 | DHFR (0.58) | DHFR | |
| SCHEMBL2463573 | 0.72 | PIK3CA (0.40) | PIK3CA | |
| SCHEMBL264497 | 0.69 | NPSR1 (0.51) | DHFR | |
| SCHEMBL29923301 | 0.68 | PIK3CA (1.00) | PIK3CAAKT1MTOR | |
| SCHEMBL21469884 | 0.68 | PIK3CA (1.00) | PIK3CAAKT1MTOR | |
| SCHEMBL10327593 | 0.66 | PIK3CA (0.59) | PIK3CAAKT1MTOR | |
| SCHEMBL30560046 | 0.65 | DHFR (0.59) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552211-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |