Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 12/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14633678 | 1.00 | CCR5 (0.86) | CCR5KCNH2 | |
| SCHEMBL2575130 | 0.94 | KCNH2 (0.90) | CCR5KCNH2 | |
| SCHEMBL2575126 | 0.94 | KCNH2 (0.90) | CCR5KCNH2 | |
| SCHEMBL1198671 | 0.93 | CCR5 (1.00) | CCR5KCNH2 | |
| SCHEMBL30227339 | 0.93 | CCR5 (1.00) | CCR5KCNH2 | |
| SCHEMBL1198672 | 0.93 | CCR5 (1.00) | CCR5KCNH2 | |
| SCHEMBL30227452 | 0.93 | CCR5 (0.89) | CCR5KCNH2 | |
| SCHEMBL13719481 | 0.92 | CCR5 (0.91) | CCR5KCNH2 | |
| SCHEMBL4020105 | 0.92 | CCR5 (0.89) | CCR5KCNH2 | |
| SCHEMBL4020109 | 0.92 | CCR5 (0.89) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2741777-B1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PULMONARY HYPERTENSION | INSERM - INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (FR) | 2017-01-18 | — | — | EP | claimed |
| US-20130023496-A1 | Combination Therapy Comprising A CCR5 Antagonist, A HIV-1 Protease Inhibtior and a Pharmacokinetic Enhancer | PHIVCO-1 LLC | 2013-01-24 | — | — | US | claimed |
| US-20130023496-A1 | Combination Therapy Comprising A CCR5 Antagonist, A HIV-1 Protease Inhibtior and a Pharmacokinetic Enhancer | PHIVCO-1 LLC | 2013-01-24 | — | — | US | disclosed |