Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14634292 | 0.92 | RIPK2 (0.44) | PTGS2MAP2K4MAP2K7RIPK2NTRK1 | |
| SCHEMBL2471505 | 0.90 | RIPK2 (0.42) | PTGS2MAP2K4MAP2K7RIPK2NTRK1 | |
| SCHEMBL14634034 | 0.90 | EPHB4 (0.49) | PTGS2MAP2K4MAP2K7RIPK2CDK1 | |
| SCHEMBL2467824 | 0.88 | CDK9 (0.42) | PTGS2MAP2K4MAP2K7RIPK2NTRK1 | |
| SCHEMBL14633488 | 0.88 | GRM4 (0.49) | MAP2K4MAP2K7RIPK2NTRK1ITK | |
| SCHEMBL2471660 | 0.88 | PTK6 (0.50) | PTGS2MAP2K4MAP2K7RIPK2 | |
| SCHEMBL2462609 | 0.87 | RIPK2 (0.48) | PTGS2MAP2K4MAP2K7RIPK2NTRK1 | |
| SCHEMBL2468759 | 0.87 | NTRK1 (0.44) | PTGS2MAP2K4MAP2K7RIPK2NTRK1 | |
| SCHEMBL14634090 | 0.85 | RIPK2 (0.46) | PTGS2MAP2K4RIPK2NTRK1CDK1 | |
| SCHEMBL2463301 | 0.85 | JAK2 (0.42) | RIPK2NTRK1JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | PTGS2 2583/4885MAP2K4 194/4885MAP2K7 72/4885 |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | PTGS2 3295/4885MAP2K4 286/4885MAP2K7 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.