Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 11/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14633956 | 0.86 | ABCB11 (0.53) | ABCB11EPHB4KDRCYP3A4CYP2D6 | |
| SCHEMBL14633741 | 0.86 | ABCB11 (0.54) | ABCB11EPHB4KDRCYP3A4CYP2D6 | |
| SCHEMBL14634054 | 0.85 | EPHB4 (0.51) | EPHB4KDRCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14634143 | 0.81 | ABCB11 (0.55) | ABCB11EPHB4KDRCYP3A4CYP2D6 | |
| SCHEMBL14634052 | 0.81 | ABCB11 (0.54) | ABCB11EPHB4KDRCYP3A4CYP2D6 | |
| SCHEMBL14634235 | 0.76 | EPHB4 (0.43) | ABCB11EPHB4KDRCYP3A4CYP2D6 | |
| SCHEMBL14634302 | 0.76 | KDR (0.43) | ABCB11EPHB4KDRCYP3A4CYP2D6 | |
| SCHEMBL14633759 | 0.75 | GRM4 (0.44) | KDRPLK4AURKAJAK2MAP4K4 | |
| SCHEMBL2468123 | 0.75 | EPHB4 (0.58) | ABCB11EPHB4KDRCYP3A4CYP2D6 | |
| SCHEMBL2432312 | 0.74 | KDR (0.54) | ABCB11EPHB4KDRCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | ABCB11 3476/4885EPHB4 2462/4885KDR 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.