SCHEMBL14634769

SCHEMBL14634769

CS(=O)(=O)c1ccc(OC2CCC(OC3CCN(C#N)CC3)CC2)nc1

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 18/20 0.63
UCHL1 P09936 1/20 0.43
USP30 Q70CQ3 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14634771 1.00 GPR119 (0.63) GPR119UCHL1USP30
SCHEMBL14634735 0.83 GPR119 (0.65) GPR119
SCHEMBL14634736 0.83 GPR119 (0.65) GPR119
SCHEMBL14634426 0.82 GPR119 (0.60) GPR119USP30
SCHEMBL14634424 0.82 GPR119 (0.60) GPR119USP30
SCHEMBL14634316 0.82 GPR119 (0.76) GPR119
SCHEMBL14634314 0.82 GPR119 (0.76) GPR119
Hydrochloric Acid SCHEMBL2557741 0.79 GPR119 (0.59) GPR119
Hydrochloric Acid SCHEMBL14634431 0.79 GPR119 (0.59) GPR119
SCHEMBL12283010 0.78 GPR119 (0.75) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, SLC5A2, SLC5A1 GPR119 1/4885UCHL1 2387/4885USP30 3396/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.