Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28390258 | 0.90 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL12553776 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL10239911 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL382019 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL376726 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL12553782 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL30069342 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL4794200 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL4303084 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 | |
| SCHEMBL4303081 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9AALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734529-B1 | BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2018-09-05 | — | — | EP | disclosed |
| US-9718828-B2 | BTK Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170008899-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-01-12 | — | — | US | disclosed |
| US-20140221333-A1 | BTK INHIBITORS | MERCK SHARP & DOHME B.V. (NL) | 2014-08-07 | — | — | US | disclosed |
| EP-2734529-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013010380-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008899-A1 | BTK INHIBITORS | BTK, SYK, ABL1 | SMN1; SMN2 3846/4885NPC1 3286/4885RAB9A 1303/4885 |
| US-20140221333-A1 | BTK INHIBITORS | BTK, SYK, ABL1 | SMN1; SMN2 3577/4885NPC1 3341/4885RAB9A 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.