Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.60 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.60 |
| ▸ | PRKX | P51817 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12190887 | 0.87 | ROCK2 (0.61) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12191092 | 0.86 | NPC1 (0.65) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12191054 | 0.86 | NPC1 (0.65) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12191130 | 0.85 | ROCK2 (0.74) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12443254 | 0.82 | NR1H4 (0.80) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12191087 | 0.82 | ROCK2 (0.57) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12191029 | 0.82 | ROCK2 (0.57) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL14640457 | 0.81 | KCNK9 (0.59) | LMNANPC1 | |
| SCHEMBL12190837 | 0.80 | ROCK2 (0.52) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 | |
| SCHEMBL12190910 | 0.80 | ROCK2 (0.52) | MAPK1ROCK2ROCK1PRKG1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007011760-A2 | INHIBITORS OF MITOTIC KINESIN | KALYPSYS, INC. (US) | 2007-01-25 | — | — | WO | disclosed |