Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 11/20 | 0.54 |
| ▸ | AURKA | O14965 | 10/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.51 |
| ▸ | KIT | P10721 | 4/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.50 |
| ▸ | CSF1R | P07333 | 3/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12049271 | 0.95 | AURKB (0.55) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL12049321 | 0.95 | AURKB (0.55) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL12049000 | 0.95 | AURKB (0.56) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL12049282 | 0.92 | AURKA (0.56) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL12049333 | 0.92 | AURKB (0.47) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL4969891 | 0.92 | PDGFRB (0.49) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL12049319 | 0.91 | AURKA (0.51) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL12049344 | 0.91 | PDGFRB (0.48) | AURKBAURKAPDGFRBCSF1RPDGFRA | |
| SCHEMBL12049272 | 0.90 | AURKA (0.52) | AURKBAURKAPDGFRBKITFLT3 | |
| SCHEMBL12048978 | 0.89 | AURKA (0.52) | AURKBAURKAPDGFRBKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004660-A1 | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004660-A1 | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines | FLT3, MCL1, CDC42BPG | AURKB 41/4885AURKA 174/4885PDGFRB 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.