Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14641600 | 0.83 | MET (0.50) | METCACNA1BCACNA1HROCK2CYP3A4 | |
| SCHEMBL14641559 | 0.81 | MET (0.49) | METCACNA1BCACNA1HSMN1; SMN2 | |
| SCHEMBL14641594 | 0.81 | MET (0.49) | METCACNA1BCACNA1HCYP3A4CYP2D6 | |
| SCHEMBL14641599 | 0.80 | MET (0.42) | METCACNA1BCACNA1HROCK2CYP3A4 | |
| SCHEMBL14641602 | 0.79 | MET (0.49) | METCACNA1BCACNA1HCYP2D6BCL2 | |
| SCHEMBL12241270 | 0.73 | MET (0.50) | MET | |
| SCHEMBL14641768 | 0.73 | MET (0.49) | METCACNA1BFAAHPIK3CAPIK3CG | |
| SCHEMBL13077318 | 0.72 | MET (0.51) | MET | |
| SCHEMBL1301780 | 0.71 | MET (0.56) | METROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12241080 | 0.71 | MET (0.51) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |