Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 3/20 | 0.39 |
| ▸ | TKT | P29401 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540447 | 0.78 | KCNH2 (0.45) | KCNH2DAOLMNACYP2C8CYP2D6 | |
| SCHEMBL8171813 | 0.76 | TRPV4 (0.47) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL14641819 | 0.75 | SMN1; SMN2 (0.44) | KDM4ELMNAGAASMN1; SMN2 | |
| SCHEMBL4237439 | 0.73 | TRPV4 (0.44) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL3819747 | 0.73 | HTR2A (0.47) | TRPV4MAOA | |
| SCHEMBL12197882 | 0.73 | DAO (0.47) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL91511 | 0.73 | TRPV4 (0.52) | TRPV4KCNH2DAOTKTKDM1A | |
| SCHEMBL24973120 | 0.72 | TRPV4 (0.43) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL19764842 | 0.72 | TRPV4 (0.43) | TRPV4DAOTKTKDM1AMAOA | |
| SCHEMBL12844982 | 0.72 | KDM1A (0.47) | TRPV4KDM1AMAOAMAOBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354414-B2 | Substituted bicyclic pyrimidines | CEPHALON, INC (US) | 2013-01-15 | — | — | US | disclosed |