Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | NRP1 | O14786 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679712 | 0.94 | ALDH1A1 (0.75) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL14615273 | 0.85 | MAPT (0.89) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL14642400 | 0.85 | TP53 (0.62) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL13679713 | 0.85 | TP53 (0.62) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL13679598 | 0.84 | TP53 (0.61) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL13679613 | 0.82 | TP53 (0.64) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL14642446 | 0.81 | TP53 (0.60) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL14615284 | 0.80 | MAPT (1.00) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL13679615 | 0.80 | MEN1 (0.70) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL14642401 | 0.80 | TP53 (0.58) | ALDH1A1MAPTMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |