Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 12/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1480214 | 0.86 | KCNA5 (0.58) | KCNA5ROCK2ROCK1 | |
| SCHEMBL1477870 | 0.83 | KCNA5 (0.72) | KCNA5KDRCSF1RPDGFRBKIT | |
| SCHEMBL14644964 | 0.83 | KCNA5 (0.58) | KCNA5KDR | |
| SCHEMBL14644961 | 0.80 | KCNA5 (0.68) | KCNA5 | |
| SCHEMBL1478379 | 0.79 | KCNA5 (0.67) | KCNA5 | |
| SCHEMBL1480523 | 0.79 | KCNA5 (0.67) | KCNA5 | |
| SCHEMBL1478669 | 0.79 | KCNA5 (0.67) | KCNA5 | |
| SCHEMBL14644969 | 0.79 | KCNA5 (0.63) | KCNA5 | |
| SCHEMBL1478403 | 0.77 | KCNA5 (0.63) | KCNA5 | |
| SCHEMBL1478452 | 0.75 | KCNA5 (0.64) | KCNA5KDRROCK2ROCK1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357809-B2 | Acyclic IKur inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-22 | — | — | US | disclosed |