⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26438139 | 0.98 | — | — | |
| SCHEMBL3039787 | 0.98 | — | — | |
| SCHEMBL18871892 | 0.84 | — | — | |
| SCHEMBL31620917 | 0.82 | — | — | |
| SCHEMBL23802491 | 0.79 | — | — | |
| SCHEMBL28455486 | 0.79 | — | — | |
| SCHEMBL28430322 | 0.79 | — | — | |
| SCHEMBL10046210 | 0.79 | — | — | |
| SCHEMBL14474695 | 0.79 | — | — | |
| SCHEMBL29185908 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311400-B2 | Methods for making conjugates from disulfide-containing proteins | NOVARTIS AG (CH) | 2022-04-26 | — | — | US | disclosed |
| CN-106536560-B | Method for preparing conjugates from disulfide-containing proteins | 诺华股份有限公司 | 2021-03-09 | — | — | CN | disclosed |
| US-20200253768-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2020-08-13 | — | — | US | disclosed |
| US-10667935-B2 | Methods for making conjugates from disulfide-containing proteins | NOVARTIS AG (CH) | 2020-06-02 | — | — | US | disclosed |
| EP-3145552-B1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2020-03-04 | — | — | EP | disclosed |
| US-10406198-B2 | Methods for making conjugates from disulfide-containing proteins | NOVARTIS AG (CH) | 2019-09-10 | — | — | US | disclosed |
| EP-2925368-B1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2019-03-27 | — | — | EP | disclosed |
| US-20190038444-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2019-02-07 | — | — | US | disclosed |
| US-10172948-B2 | Methods for oxime conjugation to ketone-modified polypeptides | NOVARTIS AG (CH) | 2019-01-08 | — | — | US | disclosed |
| US-10022256-B2 | Methods for making conjugates from disulfide-containing proteins | NOVARTIS AG (CH) | 2018-07-17 | — | — | US | disclosed |
| EP-3074048-A1 | METHODS FOR OXIME CONJUGATION TO KETONE-MODIFIED POLYPEPTIDES | Novartis AG (CH) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015179734-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2015-11-26 | — | — | WO | disclosed |
| EP-2925368-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | Novartis AG (CH) | 2015-10-07 | — | — | EP | disclosed |
| US-9149541-B2 | Tyrosine ligation process | NOVARTIS AG (CH) | 2015-10-06 | — | — | US | disclosed |
| WO-2015079376-A1 | METHODS FOR OXIME CONJUGATION TO KETONE-MODIFIED POLYPEPTIDES | NOVARTIS AG (CH) | 2015-06-04 | — | — | WO | disclosed |
| US-20150150998-A1 | METHODS FOR OXIME CONJUGATION TO KETONE-MODIFIED POLYPEPTIDES | NOVARTIS AG (CH) | 2015-06-04 | — | — | US | disclosed |
| WO-2014083505-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2014-06-05 | — | — | WO | disclosed |
| US-20140141034-A1 | TYROSINE LIGATION PROCESS | NOVARTIS AG (CH) | 2014-05-22 | — | — | US | disclosed |
| EP-2729178-A1 | TYROSINE LIGATION PROCESS | Novartis AG (CH) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013009564-A1 | TYROSINE LIGATION PROCESS | NOVARTIS AG (CH) | 2013-01-17 | — | — | WO | disclosed |