Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.81 |
| ▸ | PGR | P06401 | 6/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.81 |
| ▸ | AR | P10275 | 4/20 | 0.81 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.81 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284 | 0.98 | NR3C1 (0.83) | NR3C1PGRCYP3A4ARADORA3 | |
| Alcohol SCHEMBL9363106 | 0.97 | NR3C1 (0.81) | NR3C1PGRCYP3A4ARADORA3 | |
| SCHEMBL16474135 | 0.96 | NR3C1 (0.81) | NR3C1PGRCYP3A4ARADORA3 | |
| Fluticasone Propionate SCHEMBL1692230 | 0.95 | NR3C1 (0.90) | NR3C1PGRCYP3A4ARADORA3 | |
| Fumaric Acid SCHEMBL619903 | 0.94 | NR3C1 (0.77) | NR3C1PGRCYP3A4ARADORA3 | |
| Norflurane SCHEMBL9366922 | 0.94 | NR3C1 (0.76) | NR3C1PGRCYP3A4ARADORA3 | |
| SCHEMBL2100405 | 0.94 | NR3C1 (0.78) | NR3C1PGRCYP3A4ARADORA3 | |
| Fluticasone Propionate SCHEMBL3369738 | 0.93 | NR3C1 (0.86) | NR3C1PGRCYP3A4ARADORA3 | |
| SCHEMBL25130389 | 0.93 | NR3C1 (0.83) | NR3C1PGRCYP3A4ARADORA3 | |
| SCHEMBL16479356 | 0.92 | NR3C1 (0.78) | NR3C1PGRCYP3A4ARADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370402-B2 | Process for the preparation of fluticasone propionate form 1 | PFIZER LIMITED (GB) | 2019-08-06 | — | — | US | disclosed |
| US-20140141247-A1 | PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE FORM 1 | PFIZER LIMITED (GB) | 2014-05-22 | — | — | US | disclosed |
| EP-2729480-A1 | PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE FORM 1 | Pfizer Limited (GB) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013009591-A1 | PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE FORM 1 | PFIZER LIMITED (GB) | 2013-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370402-B2 | Process for the preparation of fluticasone propionate form 1 | CYP4A11, NR5A1, CYP2F1 | NR3C1 87/4885PGR 1000/4885CYP3A4 25/4885 |
| US-20140141247-A1 | PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE FORM 1 | CYP4A11, CYP2F1, NR5A1 | NR3C1 87/4885PGR 905/4885CYP3A4 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.