⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3437778 | 1.00 | — | — | |
| SCHEMBL1581817 | 0.80 | — | — | |
| SCHEMBL5880929 | 0.79 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL8340435 | 0.78 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL5880743 | 0.78 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL5880890 | 0.78 | OPRM1 (0.40) | — | |
| SCHEMBL5880887 | 0.78 | OPRM1 (0.40) | — | |
| SCHEMBL5881112 | 0.78 | OPRM1 (0.40) | — | |
| SCHEMBL5880846 | 0.76 | MAPT (0.46) | — | |
| SCHEMBL5880719 | 0.76 | KDM4E (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | PFIZER INC. | 2011-03-24 | — | — | US | disclosed |
| US-7807838-B2 | Methods for the preparation of HCV polymerase inhibitors | PFIZER INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20090023921-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC | 2009-01-22 | — | — | US | disclosed |
| EP-1928878-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007023381-A1 | METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |