⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10524293 | 0.97 | TP53 (0.41) | — | |
| SCHEMBL2511775 | 0.97 | TP53 (0.41) | — | |
| SCHEMBL8764246 | 0.88 | UGT2B7 (0.32) | — | |
| SCHEMBL1471843 | 0.88 | — | — | |
| SCHEMBL130488 | 0.88 | — | — | |
| SCHEMBL7802318 | 0.78 | UGT2B7 (0.31) | — | |
| SCHEMBL8718770 | 0.77 | ALDH1A1 (0.38) | — | |
| SCHEMBL7586183 | 0.77 | CPN1 (0.35) | — | |
| SCHEMBL6112257 | 0.77 | — | — | |
| SCHEMBL17292929 | 0.77 | BCL2A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020445-B1 | FUSED PYRIDINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2008-08-13 | — | — | EP | claimed |
| US-20040204421-A1 | Certain 1,3-disubstituted isoquinoline derivatives | EISAI CO., LTD. | 2004-10-14 | — | — | US | claimed |
| US-6790844-B2 | MUSCLE RELAXANTS; ANTISEROTONINE AGENT | EISAI CO., LTD (JP) | 2004-09-14 | — | — | US | claimed |
| US-20020013460-A1 | Condensed pyridine compound | EISAI CO., LTD | 2002-01-31 | — | — | US | claimed |
| US-6340759-B1 | ANTISPASMODIC AGENTS | EISAI CO., LTD. (JP) | 2002-01-22 | — | — | US | claimed |
| EP-1020445-A1 | FUSED PYRIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-07-19 | — | — | EP | claimed |
| US-8268835-B2 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | PFIZER INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268835-B2 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | PFIZER INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268835-B2 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | PFIZER INC. (US) | 2012-09-18 | — | — | US | disclosed |
| EP-1781662-B1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER (US) | 2011-04-20 | — | — | EP | disclosed |
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | PFIZER INC. | 2011-03-24 | — | — | US | disclosed |
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | PFIZER INC. | 2011-03-24 | — | — | US | disclosed |
| US-20110070187-A1 | Methods for the Preparation of HCV Polymerase Inhibitors | PFIZER INC. | 2011-03-24 | — | — | US | disclosed |
| CN-1308649-A | Catalyst system based on transition metal complexes for the copolymerization of carbon monoxide in an aqueous medium | BASF AG (DE) | 2001-08-15 | — | — | CN | disclosed |
| EP-1091995-A1 | CATALYST SYSTEMS ON THE BASIS OF TRANSITION METAL COMPLEXES FOR CARBON MONOXIDE COPOLYMERISATION IN AN AQUEOUS MEDIUM | BASF AKTIENGESELLSCHAFT (DE) | 2001-04-18 | — | — | EP | disclosed |
| EP-1091967-A1 | WATER-SOLUBLE TRANSITION METAL COMPLEXES | BASF AKTIENGESELLSCHAFT (DE) | 2001-04-18 | — | — | EP | disclosed |
| EP-1020445-A1 | FUSED PYRIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-07-19 | — | — | EP | disclosed |
| WO-2000001708-A1 | WATER-SOLUBLE TRANSITION METAL COMPLEXES | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-13 | — | — | WO | disclosed |
| WO-2000001756-A1 | CATALYST SYSTEMS ON THE BASIS OF TRANSITION METAL COMPLEXES FOR CARBON MONOXIDE COPOLYMERISATION IN AN AQUEOUS MEDIUM | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-13 | — | — | WO | disclosed |
| US-3880883-A | 2-(Hydroxyalkyl)-cyclopentane carbaldehydes | MAY & BAKER LTD | 1975-04-29 | — | — | US | disclosed |