Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990877 | 0.86 | KDM4E (0.56) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL27786917 | 0.84 | KDM4E (0.55) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL8287298 | 0.83 | KDM4E (0.54) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL14481199 | 0.81 | KDM4E (0.51) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL13177332 | 0.80 | KDM4E (0.64) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL14481613 | 0.80 | KDM4E (0.64) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL14551581 | 0.76 | KMT2A (0.63) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL30083563 | 0.76 | CPB2 (0.53) | SMN1; SMN2CPB2ALDH1A1TDP1HTT | |
| SCHEMBL13990514 | 0.73 | KDM4E (0.56) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL13341971 | 0.73 | KDM4E (0.56) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548872-A1 | CYCLOPROPANECARBOXYLIC ACID DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-01-23 | — | — | EP | disclosed |