CPB2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL454654	0.50	15/20
SCHEMBL364062	0.50	13/20
SCHEMBL364063	0.50	13/20
SCHEMBL516843	0.32	13/20
SCHEMBL589342	0.49	12/20
SCHEMBL209237	0.45	12/20
SCHEMBL43995	0.46	11/20
SCHEMBL43996	0.46	11/20
SCHEMBL574662	0.44	11/20
SCHEMBL574664	0.44	11/20
Lysine (SCHEMBL237658)	0.44	11/20
Lysine (SCHEMBL237659)	0.44	11/20
SCHEMBL515443	0.39	11/20
SCHEMBL805198	0.45	10/20
SCHEMBL421252	0.45	10/20
SCHEMBL45765	0.43	10/20
SCHEMBL214641	0.43	10/20
Acetic Acid (SCHEMBL268740)	0.42	10/20
SCHEMBL686694	0.42	10/20
SCHEMBL296013	0.41	10/20

Clinical trials — most relevant to CPB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery	PHASE4	COMPLETED
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass	PHASE2/PHASE3	COMPLETED
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery	PHASE1/PHASE2	UNKNOWN
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis	PHASE1/PHASE2	COMPLETED
Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications	PHASE1	UNKNOWN
Heparin Responses in Pediatric Patients Undergoing Cardiopulmonary Bypass.	nan	COMPLETED
Precision Medicine in the CICU: Identifying Proteomic Biomarkers	nan	ENROLLING_BY_INVITATION
Preventing Acute Chest Syndrome by Transfusion Feasibility Study	nan	COMPLETED
Clinical Assessment of Thrombosis in Children After Heart Surgery	nan	COMPLETED
Urine and Serum Biomarkers for Early Detection of Acute Kidney Injury	nan	COMPLETED
Evaluation of AKI by Measuring the NephroCheck Test After Pediatric Cardiac Surgery	nan	UNKNOWN
Markers in Acute Pancreatitis-1	nan	COMPLETED
Evaluation of Plasma Renin Concentrations in Cardiac Surgery	nan	RECRUITING
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Evaluation of Carotid IMT and Atherogenic Risk Factors in Patients With Cerebrotendinous Xanthomatosis	nan	UNKNOWN
Osteopontin Gene Polymorphism in Stroke Patients in Egypt	nan	NOT_YET_RECRUITING
Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta.	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
sPLA2 in EBC During Acute Chest Syndrome	nan	COMPLETED
The Prospective Risk Factor Evaluation & Discovery In CTEPH Study	nan	UNKNOWN
Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients	nan	RECRUITING
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery	nan	ENROLLING_BY_INVITATION
Catalytic Antibodies to Predict Uninvasively Late Transplant Failure	nan	COMPLETED
Delirium in Elderly Undergoing Cardiac Surgery and the Significance of CholinEsterase Activity	nan	COMPLETED
Presepsin as a Predictor for Postoperative Complications Following Pancreatic Resection	nan	COMPLETED
Progression of Early Subclinical Atherosclerosis	nan	ACTIVE_NOT_RECRUITING
Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial (CAF-PINT)	nan	COMPLETED
Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation?	nan	NOT_YET_RECRUITING
Inflammation Markers Over Time in Cardiovascular Disease	nan	COMPLETED
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CPB2 binder may also engage these)

Protein	Name	Similarity
Q9EQV9	—	1.000	Q9EQV9 →
Q9JHH6	—	1.000	Q9JHH6 →
Q2KIG3	—	0.998	Q2KIG3 →
Q8WXQ8	—	0.996	Q8WXQ8 →
CPA4	Carboxypeptidase A4	0.989	landscape →
CPB1	Carboxypeptidase B	0.989	landscape →
CPA3	Mast cell carboxypeptidase A	0.989	landscape →
P19223	—	0.988	P19223 →
CPA2	Carboxypeptidase A2	0.988	landscape →
P21961	—	0.988	P21961 →
P15089	—	0.988	P15089 →
P00732	—	0.988	P00732 →
P09955	—	0.987	P09955 →
P42787	—	0.987	P42787 →
Q4R7R2	—	0.987	Q4R7R2 →
Q8R4H4	—	0.987	Q8R4H4 →
Q0II73	—	0.986	Q0II73 →
Q6P8K8	—	0.986	Q6P8K8 →
P55261	—	0.986	P55261 →
B8JLQ9	—	0.985	B8JLQ9 →
P00730	—	0.985	P00730 →
P38836	—	0.984	P38836 →
Q8IVL8	—	0.984	Q8IVL8 →
P37892	—	0.983	P37892 →
P09954	—	0.983	P09954 →
A0A1S4F020	—	0.983	A0A1S4F020 →
P00731	—	0.982	P00731 →
Q504N0	—	0.981	Q504N0 →
CPA1	Carboxypeptidase A1	0.980	landscape →
Q7TPZ8	—	0.980	Q7TPZ8 →