Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 14/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14630606 | 0.99 | FGFR2 (0.54) | TNK2FGFR2IGF1RFGFR1 | |
| SCHEMBL396723 | 0.96 | FGFR2 (0.57) | TNK2FGFR2IGF1RFGFR1 | |
| SCHEMBL16748879 | 0.93 | TNK2 (0.52) | TNK2FGFR2IGF1RFGFR1 | |
| SCHEMBL14630876 | 0.86 | TNK2 (0.56) | TNK2FGFR2IGF1R | |
| SCHEMBL14630052 | 0.86 | BTK (0.49) | TNK2FGFR2IGF1R | |
| SCHEMBL14630053 | 0.86 | BTK (0.49) | TNK2FGFR2IGF1R | |
| SCHEMBL16748847 | 0.86 | TNK2 (0.56) | TNK2FGFR2IGF1RFGFR1 | |
| SCHEMBL22236165 | 0.84 | IGF1R (0.48) | TNK2FGFR2IGF1RFGFR1 | |
| SCHEMBL14637195 | 0.84 | FGFR2 (0.45) | TNK2FGFR2IGF1RFGFR1 | |
| SCHEMBL14637193 | 0.84 | FGFR2 (0.45) | TNK2FGFR2IGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548877-A1 | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors | MSD Oss B.V. (NL) | 2013-01-23 | — | — | EP | disclosed |