SCHEMBL16748879

SCHEMBL16748879

Nc1nccn2c(C3CC3)nc(Br)c12

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TNK2 Q07912 17/20 0.52
FGFR2 P21802 1/20 0.50
IGF1R P08069 1/20 0.48
FGFR1 P11362 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14630606 0.94 FGFR2 (0.54) TNK2FGFR2IGF1RFGFR1
SCHEMBL396723 0.94 FGFR2 (0.57) TNK2FGFR2IGF1RFGFR1
SCHEMBL14630053 0.93 BTK (0.49) TNK2FGFR2IGF1R
SCHEMBL14630052 0.93 BTK (0.49) TNK2FGFR2IGF1R
SCHEMBL14647353 0.93 TNK2 (0.55) TNK2FGFR2IGF1RFGFR1
SCHEMBL14630876 0.90 TNK2 (0.56) TNK2FGFR2IGF1R
SCHEMBL16748847 0.90 TNK2 (0.56) TNK2FGFR2IGF1RFGFR1
SCHEMBL14631146 0.89 TNK2 (0.47) TNK2FGFR2IGF1RFGFR1
SCHEMBL14631144 0.89 TNK2 (0.47) TNK2FGFR2IGF1RFGFR1
SCHEMBL16748882 0.87 TNK2 (0.55) TNK2FGFR2IGF1RFGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067411-A1 NEK7 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF 北京普祺医药科技股份有限公司 2025-04-03 WO disclosed
US-9822120-B2 Protein kinase inhibitors PHARMASCIENCE INC. (CA) 2017-11-21 US disclosed
US-9822120-B2 Protein kinase inhibitors PHARMASCIENCE INC. (CA) 2017-11-21 US disclosed
US-20160280711-A1 Protein Kinase Inhibitors PHARMASCIENCE INC. (CA) 2016-09-29 US disclosed
US-20160280711-A1 Protein Kinase Inhibitors PHARMASCIENCE INC. (CA) 2016-09-29 US disclosed
WO-2015074138-A1 PROTEIN KINASE INHIBITORS PHARMASCIENCE INC. (CA) 2015-05-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160280711-A1 Protein Kinase Inhibitors TEC, LCK, SRC TNK2 43/4885FGFR2 958/4885IGF1R 1739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.