Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 6/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14654246 | 0.90 | JAK2 (0.47) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL14647470 | 0.89 | IGF1R (0.51) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL14647346 | 0.89 | IGF1R (0.51) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL30449939 | 0.86 | IGF1R (0.49) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL26359420 | 0.86 | GRIN2B (0.46) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL21056239 | 0.86 | JAK2 (0.46) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL28722982 | 0.86 | JAK2 (0.46) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL14647469 | 0.84 | JAK2 (0.47) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL14654247 | 0.84 | JAK2 (0.47) | JAK2JAK1TYK2JAK3IGF1R | |
| SCHEMBL21050956 | 0.81 | JAK2 (0.42) | JAK2JAK1TYK2JAK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548877-A1 | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors | MSD Oss B.V. (NL) | 2013-01-23 | — | — | EP | disclosed |