Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 19/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648120 | 0.90 | MGLL (0.55) | MGLLFAAHHPGD | |
| SCHEMBL910688 | 0.89 | MGLL (0.58) | MGLLFAAHHPGD | |
| SCHEMBL14647916 | 0.88 | MGLL (0.62) | MGLLFAAHHPGD | |
| SCHEMBL911129 | 0.84 | MGLL (0.79) | MGLLFAAHHPGD | |
| SCHEMBL698708 | 0.84 | MGLL (0.79) | MGLLFAAHHPGD | |
| SCHEMBL14647998 | 0.84 | MGLL (0.65) | MGLLFAAHHPGD | |
| SCHEMBL14648103 | 0.83 | MGLL (0.78) | MGLLFAAH | |
| SCHEMBL911457 | 0.82 | MGLL (0.58) | MGLLFAAH | |
| SCHEMBL911516 | 0.78 | MGLL (0.62) | MGLLFAAH | |
| SCHEMBL911800 | 0.77 | MGLL (0.70) | MGLLFAAHHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |
| US-8362000-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-29 | — | — | US | disclosed |