Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 11/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14647914 | 0.90 | MGLL (0.49) | MGLLS1PR1S1PR5ALDH1A1MAPT | |
| SCHEMBL14647922 | 0.90 | MGLL (0.50) | MGLLS1PR1S1PR5USP2HPGD | |
| SCHEMBL697054 | 0.88 | KCNH2 (0.55) | MGLLALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14647949 | 0.87 | MGLL (0.48) | MGLLS1PR1S1PR5ALDH1A1SMN1; SMN2 | |
| SCHEMBL14647976 | 0.86 | S1PR5 (0.58) | MGLLS1PR1S1PR5KCNH2 | |
| SCHEMBL14648168 | 0.82 | MGLL (0.46) | MGLLS1PR1S1PR5AURKA | |
| SCHEMBL699434 | 0.81 | MGLL (0.51) | MGLLALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL911641 | 0.80 | MGLL (0.57) | MGLLS1PR1S1PR5MAPT | |
| SCHEMBL14648035 | 0.80 | MGLL (0.50) | MGLLS1PR1S1PR5KCNH2 | |
| SCHEMBL693200 | 0.78 | MGLL (0.51) | MGLLALDH1A1SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362000-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-29 | — | — | US | disclosed |