Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.57 |
| ▸ | SCN2B | O60939 | 3/20 | 0.53 |
| ▸ | SCN1A | P35498 | 3/20 | 0.53 |
| ▸ | SCN1B | Q07699 | 3/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911679 | 0.92 | MGLL (0.59) | MGLLSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL14648017 | 0.91 | MGLL (0.69) | MGLLSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL14647947 | 0.86 | MGLL (0.61) | MGLLSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL698599 | 0.84 | MGLL (0.64) | MGLLHTTTNFMEN1KMT2A | |
| SCHEMBL700090 | 0.81 | MGLL (0.72) | MGLLHTTTNFMEN1KMT2A | |
| SCHEMBL14648023 | 0.79 | MGLL (0.61) | MGLLSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL14647926 | 0.79 | MGLL (0.61) | MGLL | |
| SCHEMBL14648138 | 0.79 | MGLL (0.46) | MGLLSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL911264 | 0.77 | HTT (0.63) | MGLLHTTUSP2MEN1KMT2A | |
| SCHEMBL911565 | 0.77 | HTT (0.63) | MGLLHTTUSP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |
| US-8362000-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-29 | — | — | US | disclosed |