Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.46 |
| ▸ | TXK | P42681 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14654586 | 1.00 | BTK (0.49) | BTKTECTXKTMEM97SIGMAR1 | |
| SCHEMBL14654706 | 0.97 | TEC (0.49) | BTKTECTXK | |
| SCHEMBL14654694 | 0.97 | TEC (0.49) | BTKTECTXK | |
| SCHEMBL20411768 | 0.90 | TEC (0.45) | BTKTECTXKTMEM97SIGMAR1 | |
| SCHEMBL20411769 | 0.90 | TEC (0.54) | BTKTECTXKTMEM97SIGMAR1 | |
| SCHEMBL20411767 | 0.90 | TEC (0.54) | BTKTECTXKTMEM97SIGMAR1 | |
| SCHEMBL14637977 | 0.89 | TEC (0.53) | BTKTECTXKTMEM97SIGMAR1 | |
| SCHEMBL21783734 | 0.87 | TEC (0.47) | BTKTECTXKTMEM97SIGMAR1 | |
| SCHEMBL14637258 | 0.87 | TEC (0.56) | BTKTECTXK | |
| SCHEMBL14651434 | 0.87 | TEC (0.56) | BTKTECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11974999-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2024-05-07 | — | — | US | disclosed |
| US-11554118-B2 | Bruton's tyrosine kinase inhibitors | Liao, Xibin (US) | 2023-01-17 | — | — | US | disclosed |
| US-20140155406-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES BTK INHIBITORS | MERCK SHARP & DOHME B.V. (NL) | 2014-06-05 | — | — | US | disclosed |
| US-20140155406-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES BTK INHIBITORS | MERCK SHARP & DOHME B.V. (NL) | 2014-06-05 | — | — | US | disclosed |
| WO-2013010869-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES BTK-INHIBITORS | MSD OSS B.V. (NL) | 2013-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155406-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES BTK INHIBITORS | BTK, ABL1, SYK | BTK 1/4885TEC 17/4885TXK 151/4885 |
| US-11974999-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | BTK 1/4885TEC 28/4885TXK 247/4885 |
| US-11554118-B2 | Bruton's tyrosine kinase inhibitors | BTK, ABL1, SYK | BTK 1/4885TEC 28/4885TXK 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.