Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEC | P42680 | 1/20 | 0.47 |
| ▸ | TXK | P42681 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14651433 | 1.00 | TEC (0.47) | TECTXKBTKAADATPREP | |
| SCHEMBL20411768 | 0.97 | TEC (0.45) | TECTXKBTKAADATPREP | |
| SCHEMBL29593305 | 0.95 | PTGDR2 (0.41) | TECTXKPTGDR2TMEM97SIGMAR1 | |
| SCHEMBL28348501 | 0.90 | PREP (0.41) | TECTXKPREPPTGDR2 | |
| SCHEMBL28348505 | 0.90 | PREP (0.41) | TECTXKPREPPTGDR2 | |
| SCHEMBL14654694 | 0.89 | TEC (0.49) | TECTXKBTKAADATPREP | |
| SCHEMBL14654706 | 0.89 | TEC (0.49) | TECTXKBTKAADATPREP | |
| SCHEMBL14637258 | 0.89 | TEC (0.56) | TECTXKBTK | |
| SCHEMBL14651434 | 0.89 | TEC (0.56) | TECTXKBTK | |
| SCHEMBL24357700 | 0.87 | TEC (0.37) | TECTXKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108658990-B | Novel imidazo [1,5-a ] pyrazine Bruton kinase inhibitors | 南京科技职业学院 | 2021-03-23 | — | — | CN | disclosed |
| WO-2020043787-A1 | PROCESSES FOR THE PREPARATION OF 4-{8-AMINO-3-[(2S)-1-(BUT-2-YNOYL)-PYRROLIDIN-2-YL]IMIDAZO[1,5-A]-PYRAZIN-1-YL}N-(PYRIDIN-2-YL)-BENZAMIDE | ACERTA PHARMA B.V. (NL) | 2020-03-05 | — | — | WO | disclosed |