Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | PLD2 | O14939 | 1/20 | 0.30 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738278 | 0.84 | DPP4 (0.37) | DPP4DPP7 | |
| SCHEMBL9977795 | 0.78 | DPP4 (0.49) | DPP4DPP7NAMPTFAPDPP8 | |
| SCHEMBL14655307 | 0.77 | DPP4 (0.41) | DPP4DPP7NAMPTFAPDPP8 | |
| SCHEMBL24244520 | 0.77 | KMT2A (0.42) | DPP4DPP7NAMPTFAP | |
| SCHEMBL15203565 | 0.75 | DPP4 (0.38) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL20221436 | 0.75 | DPP4 (0.46) | DPP4DPP7NAMPTFAPDPP8 | |
| SCHEMBL28149214 | 0.73 | DPP4 (0.47) | DPP4DPP7NAMPTFAPDPP8 | |
| SCHEMBL14655943 | 0.71 | VNN1 (0.41) | — | |
| SCHEMBL15701184 | 0.71 | DPP4 (0.46) | DPP4DPP7NAMPTFAPDPP8 | |
| SCHEMBL4830838 | 0.71 | DPP4 (0.46) | DPP4DPP7NAMPTFAPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |