Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655412 | 0.98 | L3MBTL1 (0.43) | ATMMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL9723796 | 0.92 | POLB (0.47) | ATMMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL10265713 | 0.79 | ATM (0.46) | ATMMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL14738409 | 0.79 | ATM (0.46) | ATMMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL7223652 | 0.79 | POLB (0.60) | ATMMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL11494555 | 0.78 | ATM (0.42) | ATMMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL25715447 | 0.78 | ATM (0.45) | ATMMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL20905479 | 0.78 | ATM (0.45) | ATMMEN1KMT2AL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL15124306 | 0.78 | ATM (0.45) | ATMMEN1KMT2AL3MBTL1POLB | |
| SCHEMBL4323039 | 0.78 | L3MBTL1 (0.46) | ATMMEN1KMT2AL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |