Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655499 | 1.00 | DPP4 (0.53) | DPP4DPP7DPP8DPP9KCNH2 | |
| SCHEMBL27978864 | 0.90 | DPP4 (0.49) | DPP4DPP7DPP8DPP9KCNH2 | |
| SCHEMBL14655503 | 0.90 | DPP4 (0.49) | DPP4DPP7DPP8DPP9KCNH2 | |
| SCHEMBL2379157 | 0.88 | DPP4 (0.51) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL2379160 | 0.88 | DPP4 (0.51) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL15203459 | 0.84 | DPP4 (0.57) | DPP4DPP7DPP8DPP9KCNH2 | |
| SCHEMBL14655989 | 0.82 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL14656010 | 0.82 | DPP4 (0.50) | DPP4DPP7DPP8DPP9 | |
| Trifluoroacetic Acid SCHEMBL14738273 | 0.81 | DPP4 (0.43) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL15203502 | 0.81 | DPP4 (0.64) | DPP4DPP7DPP8DPP9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |