Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 2/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655949 | 0.90 | DPP4 (0.53) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL27023123 | 0.86 | JAK1 (0.42) | DPP4DPP8DPP9DPP7JAK2 | |
| SCHEMBL2455912 | 0.86 | DPP4 (0.47) | DPP4DPP8DPP9JAK2JAK1 | |
| SCHEMBL28132789 | 0.86 | DPP4 (0.47) | DPP4DPP8DPP9JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL14737849 | 0.84 | DPP4 (0.46) | DPP4DPP8DPP9JAK2JAK1 | |
| SCHEMBL15203541 | 0.83 | DPP4 (0.54) | DPP4DPP8DPP9DPP7JAK2 | |
| SCHEMBL15203437 | 0.83 | DPP4 (0.54) | DPP4DPP8DPP9DPP7JAK2 | |
| SCHEMBL14655499 | 0.82 | DPP4 (0.53) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL14655637 | 0.82 | DPP4 (0.53) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL27626212 | 0.77 | GAA (0.33) | DPP4DPP7JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |