Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.73 |
| ▸ | DPP7 | Q9UHL4 | 12/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5477707 | 0.94 | DPP4 (0.69) | DPP4DPP7KCNH2 | |
| SCHEMBL15203460 | 0.94 | DPP4 (0.69) | DPP4DPP7KCNH2 | |
| SCHEMBL6358531 | 0.92 | DPP4 (0.65) | DPP4DPP7KCNH2 | |
| SCHEMBL6360317 | 0.92 | DPP4 (0.65) | DPP4DPP7KCNH2 | |
| SCHEMBL23655651 | 0.92 | DPP4 (0.67) | DPP4DPP7KCNH2 | |
| SCHEMBL14392401 | 0.92 | DPP4 (0.67) | DPP4DPP7KCNH2 | |
| SCHEMBL6820738 | 0.92 | DPP4 (0.67) | DPP4DPP7KCNH2 | |
| SCHEMBL14392636 | 0.92 | DPP4 (0.67) | DPP4DPP7KCNH2 | |
| SCHEMBL15203483 | 0.92 | DPP4 (0.67) | DPP4DPP7KCNH2 | |
| SCHEMBL6358530 | 0.89 | DPP4 (0.61) | DPP4DPP7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |