Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.59 |
| ▸ | WNT3A | P56704 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | TPMT | P51580 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659363 | 0.89 | MAPT (0.71) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL4438295 | 0.84 | CA12 (0.65) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL7380780 | 0.84 | MAPT (0.61) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL11045656 | 0.84 | MAPT (0.61) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL1322947 | 0.84 | MAPT (0.61) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL30629388 | 0.84 | CA12 (0.65) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL4713028 | 0.82 | TSHR (0.63) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL10455919 | 0.82 | CTNNB1 (0.83) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL28881824 | 0.81 | MEN1 (0.71) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL29668496 | 0.81 | MEN1 (0.71) | MAPTALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422231-B2 | Method for inhibiting Trypanosoma cruzi | HOWARD UNIVERSITY (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150073177-A1 | METHOD FOR INHIBITING TRYPANOSOMA CRUZI | HOWARD UNIVERRSITY (US) | 2015-03-12 | — | — | US | disclosed |
| US-20140336187-A1 | METHODS FOR TREATING LEISHMANIASIS | HOWARD UNIVERSITY | 2014-11-13 | — | — | US | disclosed |
| WO-2013074930-A1 | METHODS FOR TREATING LEISHMANIASIS | HOWARD UNIVERSITY (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013016661-A1 | METHOD FOR INHIBITING TRYPANSOMA CRUZI | HOWARD UNIVERSITY (US) | 2013-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336187-A1 | METHODS FOR TREATING LEISHMANIASIS | LSS, CYP51A1, NQO1 | MAPT 4752/4885ALDH1A1 911/4885GAA 28/4885 |
| US-20150073177-A1 | METHOD FOR INHIBITING TRYPANOSOMA CRUZI | PCNA, NQO1, NQO2 | MAPT 4851/4885ALDH1A1 1806/4885GAA 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.