Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.85 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.85 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.85 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.65 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.65 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Noribogaine SCHEMBL29929979 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL29363147 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL12938454 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL17145169 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL10036152 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL31738806 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL10059710 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL15070074 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL116220 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 | |
| Noribogaine SCHEMBL13258554 | 0.92 | SLC6A4 (1.00) | SLC6A4OPRM1OPRK1SIGMAR1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783535-B2 | Substituted noribogaine | DEMERX, INC. | 2017-10-10 | — | — | US | disclosed |
| US-20150361080-A1 | SUBSTITUTED NORIBOGAINE | DEMERX, INC. (US) | 2015-12-17 | — | — | US | disclosed |
| US-20150329536-A1 | SUBSTITUTED NORIBOGAINE | DEMERX, INC. | 2015-11-19 | — | — | US | disclosed |
| US-9045481-B2 | Substituted noribogaine | DEMERX, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| US-8940728-B2 | Substituted noribogaine | DEMERX, INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-20140179685-A1 | SUBSTITUTED NORIBOGAINE | DEMERX, INC. | 2014-06-26 | — | — | US | disclosed |
| US-20140179684-A1 | SUBSTITUTED NORIBOGAINE | DEMERX, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-8362007-B1 | Substituted noribogaine | DEMERX, INC. (US) | 2013-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179685-A1 | SUBSTITUTED NORIBOGAINE | UGT2B7, GNG2, UGT1A3 | SLC6A4 466/4885OPRM1 25/4885OPRK1 33/4885 |
| US-20150329536-A1 | SUBSTITUTED NORIBOGAINE | UGT2B7, GNG2, UGT1A3 | SLC6A4 466/4885OPRM1 25/4885OPRK1 33/4885 |
| US-20150361080-A1 | SUBSTITUTED NORIBOGAINE | UGT2B7, GNG2, UGT1A3 | SLC6A4 466/4885OPRM1 25/4885OPRK1 33/4885 |
| US-20140179684-A1 | SUBSTITUTED NORIBOGAINE | UGT2B7, GNG2, UGT1A3 | SLC6A4 466/4885OPRM1 25/4885OPRK1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.