Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14410140 | 1.00 | DPP4 (0.42) | DPP4DPP8DPP9CYP3A4HSD11B1 | |
| SCHEMBL14554067 | 0.91 | DPP4 (0.43) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL2434106 | 0.91 | DPP4 (0.43) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL8269749 | 0.91 | DPP4 (0.43) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL8277771 | 0.91 | DPP4 (0.43) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL8276954 | 0.91 | DPP4 (0.43) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL15149979 | 0.91 | DPP4 (0.43) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL12969791 | 0.88 | DPP4 (0.43) | DPP4DPP8DPP9CYP3A4HSD11B1 | |
| SCHEMBL8271030 | 0.85 | DPP4 (0.62) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL13404730 | 0.85 | DPP4 (0.41) | DPP4DPP8DPP9CYP3A4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361761-B2 | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor | BRISTOL MYERS-SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |