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SCHEMBL8277771

SCHEMBL8277771

CC(C)(C)OC(=O)NC(C(=O)N1[C@H](C(N)=O)C[C@@H]2C[C@@H]21)C12CC3CC(CC(O)(C3)C1)C2

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 18/20 0.43
▸ DPP8 Q6V1X1 3/20 0.43
▸ DPP9 Q86TI2 3/20 0.43
▸ CYP3A4 P08684 2/20 0.43
▸ FAP Q12884 1/20 0.32
▸ PITRM1 Q5JRX3 1/20 0.32
▸ DPP7 Q9UHL4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8269749 1.00 DPP4 (0.43) DPP4DPP8DPP9CYP3A4FAP
SCHEMBL14554067 1.00 DPP4 (0.43) DPP4DPP8DPP9CYP3A4FAP
SCHEMBL8276954 1.00 DPP4 (0.43) DPP4DPP8DPP9CYP3A4FAP
SCHEMBL2434106 1.00 DPP4 (0.43) DPP4DPP8DPP9CYP3A4FAP
SCHEMBL15149979 1.00 DPP4 (0.43) DPP4DPP8DPP9CYP3A4FAP
SCHEMBL14664468 0.91 DPP4 (0.42) DPP4DPP8DPP9CYP3A4
SCHEMBL14410140 0.91 DPP4 (0.42) DPP4DPP8DPP9CYP3A4
SCHEMBL8269752 0.88 DPP4 (0.36) DPP4DPP8DPP9CYP3A4FAP
SCHEMBL8270356 0.88 DPP4 (0.36) DPP4DPP8DPP9CYP3A4FAP
SCHEMBL14899641 0.88 DPP4 (0.36) DPP4DPP8DPP9CYP3A4FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111138341-A Preparation method of saxagliptin 天津民祥生物医药股份有限公司 2020-05-12 — — CN claimed
CN-111138341-A Preparation method of saxagliptin 天津民祥生物医药股份有限公司 2020-05-12 — — CN disclosed
CN-111138341-A Preparation method of saxagliptin 天津民祥生物医药股份有限公司 2020-05-12 — — CN disclosed
US-8361761-B2 Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor BRISTOL MYERS-SQUIBB COMPANY (US) 2013-01-29 — — US disclosed
US-20130012723-A1 METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2013-01-10 — — US disclosed
US-20120276600-A1 Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor BRISTOL-MYERS SQUIBB COMPANY (US) 2012-11-01 — — US disclosed
US-8278462-B2 Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof BRISTOL-MYERS SQUIBB COMPANY (US) 2012-10-02 — — US disclosed
US-8222009-B2 Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor BRISTOL-MYERS SQUIBB COMPANY (US) 2012-07-17 — — US disclosed
US-20100291642-A1 Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor BRISTOL-MYERS SQUIBB COMPANY (US) 2010-11-18 — — US disclosed
US-20100274025-A1 METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2010-10-28 — — US disclosed
US-7741082-B2 Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor BRISTOL-MYERS SQUIBB COMPANY (US) 2010-06-22 — — US disclosed
US-7705033-B2 Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof BRISTOL-MYERS SQUIBB COMPANY (US) 2010-04-27 — — US disclosed
US-7611880-B2 Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2009-11-03 — — US disclosed
US-20090018311-A1 METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-15 — — US disclosed
US-7420079-B2 Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof BRISTOL-MYERS SQUIBB COMPANY (US) 2008-09-02 — — US disclosed
US-20070207527-A1 ENZYMATIC AMMONOLYSIS PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR DPP IV INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2007-09-06 — — US disclosed
US-7223573-B2 Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-29 — — US disclosed
US-7214702-B2 Process for producing a dipeptidyl peptidase IV inhibitor BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-08 — — US disclosed
WO-2005106011-A2 PROCESS FOR PREPARING DIPEPTIDYL IV INHIBITORS AND INTERMEDIATES THEREFOR BRISTOL-MYERS SQUIBB COMPANY (US) 2005-11-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100274025-A1 METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF DPP4, DPP3, DPP8 DPP4 1/4885DPP8 3/4885DPP9 6/4885
US-20090018311-A1 METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF DPP4, DPP3, DPP8 DPP4 1/4885DPP8 3/4885DPP9 6/4885
US-20120276600-A1 Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor DNPEP, DPP4, DPP8 DPP4 2/4885DPP8 3/4885DPP9 14/4885
US-20130012723-A1 METHODS AND COMPOUNDS FOR PRODUCING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREOF DPP4, DPP3, DPP8 DPP4 1/4885DPP8 3/4885DPP9 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.