Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 9/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322268 | 0.94 | MERTK (0.54) | MERTKAXLTYRO3MAPK8LMNA | |
| SCHEMBL10321666 | 0.90 | MERTK (0.49) | MERTKAXLTYRO3MAPK8LMNA | |
| SCHEMBL10322743 | 0.89 | MERTK (0.47) | MERTKAXLTYRO3MAPK8USP2 | |
| SCHEMBL10323341 | 0.88 | MERTK (0.49) | MERTKAXLTYRO3MAPK8USP2 | |
| SCHEMBL10323052 | 0.87 | MERTK (0.44) | MERTKAXLTYRO3MAPK8LMNA | |
| SCHEMBL10323970 | 0.85 | MERTK (0.54) | MERTKAXLTYRO3MAPK8EGFR | |
| SCHEMBL10323692 | 0.84 | MERTK (0.65) | MERTKAXLTYRO3TNK2 | |
| SCHEMBL10323111 | 0.82 | FLT3 (0.47) | MERTKAXLTYRO3MAPK8LMNA | |
| SCHEMBL10322741 | 0.80 | MERTK (0.49) | MERTKAXLTYRO3MAPK8LMNA | |
| SCHEMBL10322219 | 0.80 | LMNA (0.47) | MERTKMAPK8LMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362023-B2 | Pyrazolo pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 2013-01-29 | — | — | US | disclosed |