Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 11/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796978 | 0.92 | AVPR1B (0.43) | AVPR1BAVPR1ACCR3ALDH1A1HPGD | |
| SCHEMBL16857942 | 0.91 | AVPR1B (0.37) | AVPR1BGAALMNAAVPR1AALDH1A1 | |
| SCHEMBL1799770 | 0.90 | AVPR1B (0.46) | AVPR1BAVPR1A | |
| SCHEMBL1794935 | 0.89 | AVPR1B (0.42) | AVPR1BLMNAAVPR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL1800690 | 0.88 | AVPR1B (0.42) | AVPR1BAVPR1ACCR3ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1797899 | 0.88 | AVPR1B (0.39) | AVPR1BMTNR1BMTNR1ACCR3ALDH1A1 | |
| SCHEMBL1465296 | 0.88 | AVPR1B (0.38) | AVPR1BGAALMNAMTNR1BALDH1A1 | |
| SCHEMBL1465538 | 0.88 | GAA (0.38) | AVPR1BGAAAVPR1AMTNR1BMTNR1A | |
| Hydrochloric Acid SCHEMBL1799042 | 0.87 | AVPR1B (0.46) | AVPR1BAVPR1ACCR3 | |
| SCHEMBL1465263 | 0.87 | AVPR1B (0.39) | AVPR1BGAAMTNR1BMTNR1ACCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110077241-A1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | ABBOTT GMBH & CO. KG (DE) | 2011-03-31 | — | — | US | disclosed |
| US-20110071156-A1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | ABBOTT GMBH & CO. KG (DE) | 2011-03-24 | — | — | US | disclosed |
| US-7902379-B2 | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them | ABBOTT GMBH & CO. KG (DE) | 2011-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071156-A1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | OXTR, AVPR2, AVPR1A | AVPR1B 4/4885GAA 4553/4885LMNA 3137/4885 |
| US-20110077241-A1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | OXTR, AVPR2, AVPR1A | AVPR1B 4/4885GAA 4553/4885LMNA 3137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.