Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012282 | 0.86 | CSNK2A1 (0.51) | CSNK2A1RORCMEN1KMT2ALMNA | |
| SCHEMBL19612249 | 0.82 | CSNK2A1 (0.58) | CSNK2A1RORCMEN1KMT2ALMNA | |
| SCHEMBL14551877 | 0.81 | CA12 (0.41) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL19564845 | 0.76 | ERN1 (0.43) | RORCKMT2ALMNACYP1A2CYP2C9 | |
| SCHEMBL7172382 | 0.76 | CSNK2A1 (0.59) | CSNK2A1RORCMEN1KMT2ALMNA | |
| SCHEMBL14273283 | 0.76 | CSNK2A1 (0.51) | CSNK2A1RORCMEN1KMT2ALMNA | |
| SCHEMBL7429267 | 0.76 | CSNK2A1 (0.44) | CSNK2A1RORCKMT2ALMNAS1PR1 | |
| SCHEMBL14664961 | 0.74 | KMT2A (0.50) | MEN1KMT2ALMNACYP1A2GLA | |
| SCHEMBL17429154 | 0.74 | HSP90AA1 (0.48) | MEN1KMT2ALMNAKMOCYP3A4 | |
| SCHEMBL15072545 | 0.74 | MRGPRX4 (0.46) | MEN1KMT2ALMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361959-B2 | Spiro-imidazolone derivatives as glucagon receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-01-29 | — | — | US | disclosed |