Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012282 | 0.86 | CSNK2A1 (0.51) | CSNK2A1RORCKMT2AKDM4ELMNA | |
| SCHEMBL19612249 | 0.85 | CSNK2A1 (0.58) | CSNK2A1RORCALDH1A1ACACBKMT2A | |
| SCHEMBL1277797 | 0.79 | CA12 (0.48) | ALDH1A1KMT2AMAPT | |
| SCHEMBL9255317 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KMT2AKDM4ELMNAGAA | |
| SCHEMBL14664951 | 0.76 | CSNK2A1 (0.49) | CSNK2A1RORCKMT2AGLAKDM4E | |
| SCHEMBL8417 | 0.75 | ALDH1A1 (0.40) | ALDH1A1KMT2AGLAPARP10BRD4 | |
| SCHEMBL3140756 | 0.75 | RXRA (0.43) | ALDH1A1KMT2AGLAPARP10BRD4 | |
| SCHEMBL14257716 | 0.73 | CSNK2A1 (0.43) | CSNK2A1RORCALDH1A1ACACBKMT2A | |
| SCHEMBL8959042 | 0.73 | CSNK2A1 (0.50) | CSNK2A1RORCGLAKDM4EHPGD | |
| SCHEMBL3721647 | 0.73 | LMNA (0.53) | ALDH1A1KMT2AKDM4ELMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192165-A2 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | Bristol-Myers Squibb Pharma Company (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077010-A2 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |