Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.72 |
| ▸ | AR | P10275 | 10/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | SHBG | P04278 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13103488 | 1.00 | PGR (0.72) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL13146712 | 0.90 | PGR (0.61) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL14668731 | 0.86 | PGR (0.79) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL14256379 | 0.86 | PGR (0.79) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL16329005 | 0.86 | PGR (0.79) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL8025172 | 0.86 | PGR (0.79) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL18220876 | 0.86 | PGR (0.79) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL13103061 | 0.85 | CYP19A1 (0.60) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL14256416 | 0.84 | PGR (0.64) | PGRARLMNANR3C1ABCC4 | |
| SCHEMBL14256378 | 0.84 | PGR (0.64) | PGRARLMNANR3C1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266998-B1 | Process for obtaining 17-spirolactones in steroids | CRYSTAL PHARMA SAU (ES) | 2013-07-24 | — | — | EP | disclosed |
| US-8383809-B2 | Process for the preparation of drospirenone | NEWCHEM S.P.A. (IT) | 2013-02-26 | — | — | US | disclosed |
| EP-2551275-A1 | Process for the preparation of drospirenone | INDUSTRIALE CHIMICA S.r.l. (IT) | 2013-01-30 | — | — | EP | disclosed |