Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 11/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL341654 | 1.00 | HSD17B10 (0.38) | HSD17B10KDM4EMEN1ALDH1A1KMT2A | |
| Trifluoroacetic Acid SCHEMBL341656 | 1.00 | HSD17B10 (0.38) | HSD17B10KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL342895 | 0.95 | KDM4E (0.41) | HSD17B10KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL342896 | 0.95 | KDM4E (0.41) | HSD17B10KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL342894 | 0.95 | KDM4E (0.41) | HSD17B10KDM4EMEN1ALDH1A1KMT2A | |
| Trifluoroacetic Acid SCHEMBL343440 | 0.89 | RBP4 (0.35) | RBP4PPARGRETGAA | |
| Trifluoroacetic Acid SCHEMBL343442 | 0.89 | RBP4 (0.35) | RBP4PPARGRETGAA | |
| SCHEMBL341655 | 0.89 | RBP4 (0.35) | HSD17B10KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL342078 | 0.87 | HSD17B10 (0.35) | HSD17B10KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL342080 | 0.87 | HSD17B10 (0.35) | HSD17B10KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367690-B2 | Aminopyridine derivatives having aurora a selective inhibitory action | VERTEX PHARMACEUTICALS INC. (US) | 2013-02-05 | — | — | US | disclosed |