Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223392 | 0.78 | HDAC1 (0.41) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL12517097 | 0.73 | HDAC8 (0.40) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2275210 | 0.73 | HDAC8 (0.40) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2275217 | 0.73 | HDAC8 (0.40) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2267220 | 0.73 | HDAC8 (0.42) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL12518546 | 0.71 | HDAC8 (0.40) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2267431 | 0.71 | HDAC8 (0.40) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2267435 | 0.71 | HDAC8 (0.40) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2271369 | 0.71 | ALDH1A1 (0.36) | LMNAHDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2222330 | 0.71 | HDAC1 (0.46) | LMNAHDAC1HDAC8HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088181-A9 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | WO | disclosed |