⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2811478 | 0.98 | — | — | |
| Acetic Acid SCHEMBL3134326 | 0.88 | ALDH1A1 (0.60) | — | |
| SCHEMBL1314765 | 0.76 | — | — | |
| SCHEMBL158422 | 0.76 | — | — | |
| SCHEMBL14434069 | 0.76 | — | — | |
| SCHEMBL26545914 | 0.76 | — | — | |
| SCHEMBL31461084 | 0.74 | — | — | |
| SCHEMBL31461088 | 0.74 | — | — | |
| Ammonia Solution, Strong SCHEMBL28224778 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL5013504 | 0.74 | ALDH1A1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4698521-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXY-4,5-DIHYDROTHIAZOLE-2-CARBONITRILE AND DERIVATIVES THEREOF | F. Hoffmann-La Roche AG (CH) | 2026-02-25 | — | — | EP | claimed |
| WO-2024218026-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXY-4,5-DIHYDROTHIAZOLE-2-CARBONITRILE AND DERIVATIVES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2024-10-24 | — | — | WO | claimed |
| CN-111825633-B | Method for synthesizing 2-guanidyl thiazole compounds by one-pot method | 西华大学 | 2023-11-17 | — | — | CN | claimed |
| EP-4698521-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXY-4,5-DIHYDROTHIAZOLE-2-CARBONITRILE AND DERIVATIVES THEREOF | F. Hoffmann-La Roche AG (CH) | 2026-02-25 | — | — | EP | disclosed |
| EP-4698521-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXY-4,5-DIHYDROTHIAZOLE-2-CARBONITRILE AND DERIVATIVES THEREOF | F. Hoffmann-La Roche AG (CH) | 2026-02-25 | — | — | EP | disclosed |
| US-12351575-B2 | 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2025-07-08 | — | — | US | disclosed |
| WO-2024218026-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXY-4,5-DIHYDROTHIAZOLE-2-CARBONITRILE AND DERIVATIVES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2024-10-24 | — | — | WO | disclosed |
| WO-2024218026-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXY-4,5-DIHYDROTHIAZOLE-2-CARBONITRILE AND DERIVATIVES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2024-10-24 | — | — | WO | disclosed |
| US-20240317705-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2024-09-26 | — | — | US | disclosed |
| CN-114341137-B | Dihydropyrimidine derivatives and uses thereof | 西藏天晟泰丰药业有限公司 | 2024-09-20 | — | — | CN | disclosed |
| EP-4289842-A1 | PHENYLDIHYDROPYRIMIDINE COMPOUND AND USE THEREOF | Hepagene Therapeutics (HK) Limited (HK) | 2023-12-13 | — | — | EP | disclosed |
| WO-2001068647-A1 | MEDICAMENTS AGAINST VIRAL DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-20 | — | — | WO | disclosed |
| EP-1073653-A1 | NOVEL 2-HETEROCYCLICALLY SUBSTITUTED DIHYDROPYRIMIDINES | BAYER AG (DE) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054329-A1 | NOVEL 2-HETEROCYCLICALLY SUBSTITUTED DIHYDROPYRIMIDINES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-10-28 | — | — | WO | disclosed |
| EP-0269239-B1 | Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof | PFIZER (US) | 1994-06-08 | — | — | EP | disclosed |
| US-4997949-A | Antiulcer | PFIZER INC. (US) | 1991-03-05 | — | — | US | disclosed |
| US-4997981-A | Alkylation | PFIZER INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0269239-A2 | Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof | PFIZER INC. (US) | 1988-06-01 | — | — | EP | disclosed |
| WO-1988003141-A1 | PROCESSES FOR 2-(1-PENTYL-3-GUANIDINO)-4-(2-METHYL-4-IMIDAZOLYL)THIAZOLE AND ANALOGS | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |
| WO-1988003140-A1 | CRYSTALLINE 2-(1-PENTYL-3-GUANIDINO)-4-(2-METHYL-4-IMIDAZOLYL)THIAZOLE DIHYDROCHLORIDE TRIHYDRATE | PFIZER INC. (US) | 1988-05-05 | — | — | WO | disclosed |