Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPM1B | O75688 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8608076 | 0.85 | ALDH1A1 (0.51) | MAPTALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL4221 | 0.82 | — | — | |
| SCHEMBL237380 | 0.82 | MAPT (0.60) | MAPTALDH1A1MEN1KMT2APPM1B | |
| SCHEMBL8891623 | 0.82 | MAPT (0.60) | MAPTALDH1A1MEN1KMT2APPM1B | |
| SCHEMBL2375356 | 0.82 | MAPT (0.60) | MAPTALDH1A1MEN1KMT2APPM1B | |
| Hydrochloric Acid SCHEMBL28788727 | 0.80 | — | — | |
| SCHEMBL6058686 | 0.80 | MAPT (0.50) | MAPTALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL24696275 | 0.79 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL29328120 | 0.79 | MAPT (0.49) | MAPTALDH1A1MEN1KMT2ATSHR | |
| Hydrochloric Acid SCHEMBL27635791 | 0.78 | MAPT (0.56) | MAPTALDH1A1MEN1KMT2APPM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367691-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2013-02-05 | — | — | US | disclosed |