Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8692897 | 0.94 | CA1 (0.66) | CA1CA2POLBHDAC8HDAC3 | |
| SCHEMBL4757472 | 0.87 | CA1 (0.59) | CA1CA2POLBKMT2ANPC1 | |
| SCHEMBL937131 | 0.87 | CA1 (0.59) | CA1CA2POLBHDAC8HDAC3 | |
| SCHEMBL6274441 | 0.87 | CA1 (0.58) | CA1CA2HDAC8HDAC3HDAC1 | |
| SCHEMBL3955534 | 0.86 | CA1 (0.65) | CA1CA2POLBHDAC8HDAC3 | |
| SCHEMBL14679376 | 0.85 | POLB (0.54) | CA1CA2POLBHDAC8HDAC3 | |
| SCHEMBL4758298 | 0.85 | CA1 (0.57) | CA1CA2POLBHDAC8HDAC3 | |
| SCHEMBL4412010 | 0.85 | CA1 (0.57) | CA1CA2HDAC8HDAC3HDAC1 | |
| SCHEMBL4625768 | 0.85 | MAPT (0.57) | CA1CA2POLBHDAC8HDAC3 | |
| SCHEMBL14679432 | 0.84 | CA1 (0.60) | CA1CA2POLBHDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |