Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673493 | 0.82 | IKBKB (0.50) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL13139605 | 0.79 | IKBKB (0.59) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3508452 | 0.79 | IKBKB (0.59) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3671299 | 0.78 | IKBKB (0.46) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3508553 | 0.75 | IKBKB (0.54) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3512249 | 0.75 | IKBKB (0.54) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3507771 | 0.73 | IKBKB (0.73) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3507692 | 0.73 | IKBKB (0.67) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3508652 | 0.73 | IKBKB (0.67) | IKBKBGAAALDH1A1MEN1KMT2A | |
| SCHEMBL613585 | 0.72 | IKBKB (0.71) | IKBKBGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367706-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-02-05 | — | — | US | disclosed |