Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8230876 | 0.83 | ADORA2A (0.79) | ADORA2AHPGDKDM4EALDH1A1KMT2A | |
| SCHEMBL22382554 | 0.79 | HPGD (0.55) | ADORA2AHPGDKMT2AMAPTTDP1 | |
| SCHEMBL1467861 | 0.78 | ADORA2A (1.00) | ADORA2A | |
| SCHEMBL2362229 | 0.78 | KDM4E (0.58) | ADORA2AHPGDKDM4EALDH1A1KMT2A | |
| SCHEMBL5369293 | 0.77 | ADORA2A (0.82) | ADORA2A | |
| SCHEMBL8232572 | 0.76 | ADORA2A (0.69) | ADORA2A | |
| SCHEMBL22382310 | 0.75 | PTGER4 (0.63) | ADORA2AKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL19436514 | 0.73 | KDM4E (0.56) | ADORA2AKDM4EKMT2ATLR8PTGER4 | |
| SCHEMBL16509700 | 0.73 | TSHR (0.59) | ADORA2AHPGDKDM4EKMT2AGAA | |
| Bromide SCHEMBL23227960 | 0.73 | KDM4E (0.55) | ADORA2AKDM4EKMT2ATLR8PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071130-A1 | 2-AMINOBENZIMIDAZOLES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071130-A1 | 2-AMINOBENZIMIDAZOLES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071130-A1 | 2-AMINOBENZIMIDAZOLES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| WO-2007133983-A2 | 2-AMINOBENZIMIDAZOLES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-11-22 | — | — | WO | disclosed |
| WO-2007133983-A2 | 2-AMINOBENZIMIDAZOLES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071130-A1 | 2-AMINOBENZIMIDAZOLES FOR TREATING NEURODEGENERATIVE DISEASES | ADORA2A, ADORA2B, ADORA1 | ADORA2A 1/4885HPGD 1570/4885KDM4E 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.