Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 6/20 | 0.52 |
| ▸ | FLT1 | P17948 | 6/20 | 0.52 |
| ▸ | CSF1R | P07333 | 5/20 | 0.52 |
| ▸ | AXL | P30530 | 5/20 | 0.52 |
| ▸ | KIT | P10721 | 5/20 | 0.52 |
| ▸ | GSK3B | P49841 | 4/20 | 0.52 |
| ▸ | LCK | P06239 | 4/20 | 0.52 |
| ▸ | LYN | P07948 | 4/20 | 0.52 |
| ▸ | FLT3 | P36888 | 4/20 | 0.52 |
| ▸ | BLK | P51451 | 4/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | PLK4 | O00444 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28776688 | 0.96 | TYRO3 (0.54) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL59056 | 0.94 | TYRO3 (0.55) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL5031566 | 0.93 | FGFR1 (0.51) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL59234 | 0.91 | TYRO3 (0.51) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL58316 | 0.90 | TYRO3 (0.52) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL59352 | 0.89 | TYRO3 (0.61) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL5036616 | 0.88 | RET (0.52) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL59884 | 0.88 | TYRO3 (0.54) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL65378 | 0.88 | TYRO3 (0.52) | TYRO3FLT1CSF1RAXLKIT | |
| SCHEMBL60212 | 0.88 | TYRO3 (0.55) | TYRO3FLT1CSF1RAXLKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2013-02-13 | — | — | EP | claimed |