Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 10/20 | 0.54 |
| ▸ | AXL | P30530 | 5/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.54 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686127 | 0.96 | TYRO3 (0.52) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL58316 | 0.93 | TYRO3 (0.52) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL5036616 | 0.93 | RET (0.52) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL59352 | 0.92 | TYRO3 (0.61) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL59056 | 0.91 | TYRO3 (0.55) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL59884 | 0.91 | TYRO3 (0.54) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL65378 | 0.91 | TYRO3 (0.52) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL27768250 | 0.91 | TYRO3 (0.46) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL60212 | 0.90 | TYRO3 (0.55) | TYRO3AXLCSF1RFLT1GSK3A | |
| SCHEMBL842074 | 0.90 | TYRO3 (0.49) | TYRO3AXLCSF1RFLT1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | claimed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |