Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 7/20 | 1.00 |
| ▸ | F2 | P00734 | 10/20 | 0.79 |
| ▸ | MAPT | P10636 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | KLK7 | P49862 | 3/20 | 0.79 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.79 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.79 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.79 |
| ▸ | EGFR | P00533 | 1/20 | 0.74 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.74 |
| ▸ | TUBB | P07437 | 1/20 | 0.74 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.74 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.74 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.74 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.74 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.74 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.74 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.74 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.74 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561654 | 0.88 | F2 (1.00) | F12F2MAPTKMT2AKLK7 | |
| SCHEMBL2554237 | 0.87 | F12 (0.76) | F12F2MAPTKMT2AKLK7 | |
| SCHEMBL14688964 | 0.85 | F12 (0.73) | F12F2MAPTKMT2AKLK7 | |
| SCHEMBL2568934 | 0.81 | F2 (1.00) | F12F2MAPTKMT2AKLK7 | |
| SCHEMBL2567843 | 0.78 | KLK3 (0.67) | F12F2MAPTKMT2AKLK7 | |
| SCHEMBL14688640 | 0.76 | F12 (0.82) | F12F2 | |
| SCHEMBL2553179 | 0.76 | MAPT (0.81) | F2MAPTKMT2ASMN1; SMN2POLB | |
| SCHEMBL1248065 | 0.75 | JAK1 (0.64) | F12F2MAPTHSD17B10 | |
| SCHEMBL2553684 | 0.75 | KLKB1 (0.83) | F2MAPTKMT2ASMN1; SMN2POLB | |
| SCHEMBL1251048 | 0.75 | F2 (0.60) | F12F2MAPTKMT2AKLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10653674-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | VERSEON CORPORATION (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180214418-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2018-08-02 | — | — | US | disclosed |
| US-9963440-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | VERSEON CORPORATION (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170326125-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2017-11-16 | — | — | US | disclosed |
| US-9533967-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | VERSEON CORPORATION (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160256440-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-09-08 | — | — | US | disclosed |
| US-20160136177-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-05-19 | — | — | US | disclosed |
| US-20160122333-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-05-05 | — | — | US | disclosed |
| US-20130040950-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON CORPORATION (US) | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160256440-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | F12 33/4885F2 4/4885MAPT 1854/4885 |
| US-20170326125-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | F12 33/4885F2 4/4885MAPT 1854/4885 |
| US-20180214418-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | F12 33/4885F2 4/4885MAPT 1854/4885 |
| US-20160122333-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | F12 33/4885F2 4/4885MAPT 1854/4885 |
| US-10653674-B2 | Multisubstituted aromatic compounds as inhibitors of thrombin | TFPI, PLAT, SERPINC1 | F12 33/4885F2 4/4885MAPT 1854/4885 |
| US-20160136177-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | F12 33/4885F2 4/4885MAPT 1854/4885 |
| US-20130040950-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | TFPI, PLAT, SERPINC1 | F12 33/4885F2 4/4885MAPT 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.